GENTAMICIN (UNII: T6Z9V48IKG) (GENTAMICIN - UNII:T6Z9V48IKG)Įurofins BioPharma Product Testing Torronto, Inc. MICONAZOLE NITRATE (UNII: VW4H1CYW1K) (MICONAZOLE - UNII:7NNO0D7S5M) HYDROCORTISONE ACEPONATE (UNII: 2340UP1L2G) (HYDROCORTISONE - UNII:WI4X0X7BPJ) OTIC hydrocortisone aceponate, miconazole nitrate, and gentamicin sulfate suspension The mall is one of the top three shopping destinations in the Midtown region. It houses a department store, specialty shops, and a food court. Dogs in the 3X and 5X groups also had higher liver weights and greater food consumption. The Park Plaza Mall is a large and popular shopping centre in Little Rock, Arkansas. Dogs in the 3X and 5X groups demonstrated elevations in AST and ALP, while dogs in the 1X, 3X, and 5X groups had elevated cholesterol, total protein, and albuminlevels. The ACTH stimulation test results are consistent with systemic absorption of topical corticosteroids causing suppression of the hypothalamic-pituitary-adrenal axis. Baseline cortisol values and the cortisol response to ACTH stimulation were lower in treated dogs compared to the control dogs. Renal tubular crystals were present in the cortex and medulla (0X, 1X, 3X, and 5X groups) and mild renal tubular basophilia and atrophy were present in one 5X group dog. Hypersensitivity reactions in the external ear canal and inner pinnae were seen in all EASOTIC Otic Suspension groups and included mild to severe aural erythema (3X group), papules and ulceration (1X and 5X groups), otitis externa (3X and 5X groups), and otitis media (5X group). In the target animal safety study, EASOTIC Otic Suspension was administered at 0X, 1X, 3X and 5X the recommended dose for 15 consecutive days (3 times the recommended treatment duration) in laboratory Beagles, with 8 dogs per group. Immediately discontinue use of EASOTIC Otic Suspension if hearing loss or signs of vestibular dysfunction are observed during treatment (see ADVERSE REACTIONS). The use of EASOTIC Otic Suspension in a dog with a damaged tympanic membrane can result in damage to the structures of the ear associated with hearing and balance or in transmission of the infection to the middle or inner ear. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.Īnimal Warnings: As a class, aminoglycoside antibiotics are associated with ototoxicty, vestibular dysfunction and renal toxicity. In case of accidental ingestion by humans, contact a physician immediately. Humans with known or suspected hypersensitivity to hydrocortisone, aminoglycoside antibiotics, or azole antifungals should not handle this product. In case of accidental skin contact, wash area thoroughly with water. Keep this and all drugs out of reach of children.
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